Copper Storage Disease

descriptionOverview

Copper storage disease occurs when the liver accumulates toxic levels of copper due to a genetic defect in copper metabolism. Over time, copper buildup damages liver cells, causing chronic hepatitis and eventually liver failure. Some breeds have a known genetic mutation; in others, excessive dietary copper may contribute. It can be managed with copper-restricted diets and copper-chelating medications.

searchSymptoms to Watch For

• warningOften no symptoms until significant liver damage has occurred
• warningJaundice (yellowing of eyes and gums)
• warningVomiting and loss of appetite
• warningDark urine
• warningLethargy and weight loss

restaurantHow Nutrition Helps

Copper-restricted diets are the primary management strategy. This means avoiding foods with added copper supplements and high-copper ingredients like organ meats (especially liver), shellfish, and certain legumes. Zinc supplementation blocks copper absorption in the intestines and is often used alongside dietary restriction. High-quality protein from low-copper sources supports liver recovery.

verifiedPrevention Tips

• check_circleGenetic testing for at-risk breeds before breeding
• check_circleAnnual liver enzyme monitoring for predisposed breeds
• check_circleAvoid liver, shellfish, and high-copper supplements
• check_circleUse copper-restricted diets for diagnosed dogs
• check_circleZinc supplementation under veterinary guidance